Strategy

In order to develop an appropriate multi-stage malaria vaccine we will:

–Find the two best malaria vaccine antigen candidates for each malaria stage:

• Sporozoite
• Liver-stage
• Blood-stage
• Sexual stage

–Find the best virus-like particle (VLP) to present three of the above

–Conduct GMP manufacture of two new bivalent VLPs and a new clinical adjuvant

–Conduct clinical trials of the best malaria vaccine candidates for the malaria stages:

• Pre-erythrocytic
• Blood-stage
• Sexual-stage