Pre-Erythrocytic Malaria Vaccines

Developing new and improved vaccines/vaccination regimes against malaria from the point of injection of parasites from an infected mosquito to the emergence of blood-stage parasites from the liver. In addition we aim to better understand the natural and vaccine-induced immune response during this stage of malaria.

Our key areas of research include:

1. Improving and optimising T cell inducing vaccines against the liver-stage of malaria. 

2. Improving and understanding antibody based vaccines against the sporozoite stage of malaria. 

3. Screening of new liver-stage malaria antigens for the ability of T cells to kill malaria infected hepatocytes. 

4. Identifying sporozoite proteins required for hepatocyte invasion. 

5. Evaluating candidate antigens from proteomic analysis of sporozoites and immunity to sporozoites